Summary: The dynamic reactions of B. glabrata on intravasal loads of 20–1000 μg glucose·g live fresh wt-1 were studied in standard fed snails (SFS). Starved snails (SS) and snails infected with S. mansoni (IS) were given 100–500 μg glucose·g fresh live wt-1. Mean hemolymph glucose level was 12.1 mg·100 ml-1 in SFS. It was not significantly lower in SS (10.7 mg·100 ml-1), but significantly reduced in IS (8.5 mg·100 ml-1). Since hemolymph volumes were significantly increased in SS, the amount of circulating glucose (pool) did not change (75 μg·g body weight-1) compared to SFS (62 μg·g-1). It was, however, reduced to 41 μg·g-1 in IS. In SFS the circulating glucose pool had to be doubled to induce significantly elimination of the injected glucose. Tripled pools were eliminated with half-times of 45 min, whereas lower and higher glucose loads were eliminated significantly slower (half-times: 80–105 min). Glucose tolerance of SS was reduced: half-times were doubled, and metabolization of injected glucose was reduced. Since tissue fresh weights were lowered by 40%, absolute incorporation of 14C from labeled glucose was lowered, but specific incorporation (per mg) was higher than in SFS and IS. Glucose tolerance of IS was increased: metabolic clearance rates rose by 70% and half-times were shortened by 30%, though absolute and specific rates of 14C incorporation were lowered. However, IS lost 25% of the label to the water, whereas SFS lost 12% and SS only lost 8%. Using the antimetabolite 2-deoxyglucose, 80% of the losses proved to be glucose in IS, and 50% in SFS. The present results suggest the existence of a glucostatic regulation in B. glabrata with lower sensitivity and capacity than in mammals. As to glucose tolerance, the often reported parallelism in metabolic shifts induced by starvation and parasitic infection was not confirmed.

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   |clé=     ISTEX:69695FA3FEC7A9D2D4C7E4D04712AEEB847625DF
   |texte=   Comparative glucose tolerance studies in the freshwater snail Biomphalaria glabrata : influence of starvation and infection with the trematode Schistosoma mansoni
}}